Have you ever visited a Plasma collection facility? Have you heard the screaming ads on media of payments of up to $300 USD for 5 plasma donations? I have been to a few local Plasma collection centers. As well, I am aware of the lack of consistent drug tests and thorough screenings of donors. It is quite scary.
Plasma is the white liquid of blood. Contained within the plasma are B Cells, or White Blood Cells (WBC). The B cells are the bodies immune system. The B and T cells, through a complex interaction, seek out and destroy bacteria, fungi, and viruses and protect the body.
There are specialized B cells, called “IMMUNOGLOBULINS”‘which are IGg, IGa, IGm, and IGe. Patients with CVID, or a Primary Immune Deficiency (PID) do not make any, or enough, IGG and are also deficient in either IGa or IGm (IGG is the main immunoglobulin derived from donor plasma). In order to survive, a patient wit CVID or a PID must infuse donor IGg, weekly via SCIG. Or every 3-4 weeks via IVIG for the rest of their lives. IGg cells die rather quickly, and patients must continue infusing for protection, and survival. The “normal” patients body will quickly replenish the IGG (plasma) donated or needed.
The lack of thorough screening of donors, leaves patients who rely on IGG in a dangerous and deadly game of roulette. Especially for myself, as I am on the receiving end of the IGg that is derived from the 1000s-10,000s donor IGg in one month alone.
I’ve purposely avoided the Manufacturers product that has a lack of quality control of the individual Plasma donors.
Until a facility, recently opened in my state which is the manufacturer of my product. Last year, prior to the facility opening, I voiced my concerns, about the lack of donor screening. I was reassured the manufacturer (of my product) would have stringent guidelines on donor policies. To my utter amazement, shock and horror. A recent ad on Craigslist appeared, using the same schemes to get donors in the door.
One can just imagine the blood born illnesses and diseases that can slip through the Plasma to IGg process. Ultimately, patients on the receiving end are really “rolling the dice”. We need the IGg to survive, however the IGg is harvested from millions of donors that (mostly, but not all) have underlying addictions, diseases, and blood born contamination that can harm or kill us.
As part of the extraction of Immunoglobulins (IGg; IGe), from the donor plasma, IGg has IGe, which is also infused into the patient. As a byproduct of the IGg Infusion, IGe is also infused by SCIG. IGe cells are the “cells” that contain individual donor ALLERGIES.
Patients, once with no history of specific and severe allergies, are now developing peanut and grass allergies (Zdziarski, P., et. al., 2017).
Hmm, if it’s that easy to develop new allergies from a byproduct of donor IGg, what else can the patient be contaminated with? A serious issue, not likely to be addressed by the manufacturers.
Be aware, if you do infuse biologicals via subcutaneous (SCIG) and develop a new allergy, the evidence points to lack of donor screening, and infusions of IGg.
Passive blood anaphylaxis: subcutaneous immunoglobulins are a cause of ongoing passive anaphylactic reaction. Zdziarski, P., Gamian A., Majda J., Korzeniowska-Kowal A. (2017). Allergy, Asthma & Clinical Immunology 13:41. Retrieved 11/08/17: https://aacijournal.biomedcentral.com/articles/10.1186/s13223-017-0213-x