How Thoroughly are Plasma Donors Screened?

Have you ever visited a Plasma collection facility? Have you heard the screaming ads on media of payments of up to $300 USD for 5 Plasma visits? I have been to a few local Plasma collection centers. As well, I am aware of the lack of consistent drug testing and thourough screening of donors.
Patients need the IGg to survive. However the IGg is harvested from millions of donors that (mostly) have underlying addictions, diseases, and blood born contamination that can harm or kill us. A new study points to evidence that patients receiving IGg infusions via subcutaneous AKA SCIG routes are developing new allergies from the IGe in the final Infusion-ready product of Immunogobulins (IGg) derived from DONOR ALLERGIES.

Have you ever visited a Plasma collection facility? Have you heard the screaming ads on media of payments of up to $300 USD for 5 plasma donations? I have been to a few local Plasma collection centers. As well, I am aware of the lack of consistent drug tests and thorough screenings of donors. It is quite scary.

Plasma is the white liquid of blood. Contained within the plasma are B Cells, or White Blood Cells (WBC). The B cells are the bodies immune system. The B and T cells, through a complex interaction, seek out and destroy bacteria, fungi, and viruses and protect the body.

Complex interaction of the human immune system, immunoglobulins seek out and destroy invaders.

There are specialized B cells, called “IMMUNOGLOBULINS”‘which are IGg, IGa, IGm, and IGe. Patients with CVID, or a Primary Immune Deficiency (PID) do not make any, or enough, IGG and are also deficient in either IGa or IGm (IGG is the main immunoglobulin derived from donor plasma). In order to survive, a patient wit CVID or a PID must infuse donor IGg, weekly via SCIG. Or every 3-4 weeks via IVIG for the rest of their lives. IGg cells die rather quickly, and patients must continue infusing for protection, and survival. The “normal” patients body will quickly replenish the IGG (plasma) donated or needed.

The lack of thorough screening of donors, leaves patients who rely on IGG in a dangerous and deadly game of roulette. Especially for myself, as I am on the receiving end of the IGg that is derived from the 1000s-10,000s donor IGg in one month alone.

INSIDE VIEW Of the machine that separates the red blood cells from the plasma (which is yellowish) and returns the red blood cells to the donor. The Plasma is separated and combined with tens of thousands of other donors plasma. The result is what are called: IMMUNOGLOBULINS (IGg, and smaller amounts of IGa AND IGe).

I’ve purposely avoided the Manufacturers product that has a lack of quality control of the individual Plasma donors.

Until a facility, recently opened in my state which is the manufacturer of my product. Last year, prior to the facility opening, I voiced my concerns, about the lack of donor screening. I was reassured the manufacturer (of my product) would have stringent guidelines on donor policies. To my utter amazement, shock and horror. A recent ad on Craigslist appeared, using the same schemes to get donors in the door.

Patients Concerns: Safety Protocol of Plasma Donors are laxed, or non-existent.

One can just imagine the blood born illnesses and diseases that can slip through the Plasma to IGg process. Ultimately, patients on the receiving end are really “rolling the dice”. We need the IGg to survive, however the IGg is harvested from millions of donors that (mostly, but not all) have underlying addictions, diseases, and blood born contamination that can harm or kill us.

As part of the extraction of Immunoglobulins (IGg; IGe), from the donor plasma, IGg has IGe, which is also infused into the patient. As a byproduct of the IGg Infusion, IGe is also infused by SCIG. IGe cells are the “cells” that contain individual donor ALLERGIES.
Patients, once with no history of specific and severe allergies, are now developing peanut and grass allergies (Zdziarski, P., et. al., 2017).

Hmm, if it’s that easy to develop new allergies from a byproduct of donor IGg, what else can the patient be contaminated with? A serious issue, not likely to be addressed by the manufacturers.

Be aware, if you do infuse biologicals via subcutaneous (SCIG) and develop a new allergy, the evidence points to lack of donor screening, and infusions of IGg.

https://aacijournal.biomedcentral.com/articles/10.1186/s13223-017-0213-x

Passive blood anaphylaxis: subcutaneous immunoglobulins are a cause of ongoing passive anaphylactic reaction. Zdziarski, P., Gamian A., Majda J., Korzeniowska-Kowal A. (2017). Allergy, Asthma & Clinical Immunology 13:41. Retrieved 11/08/17: https://aacijournal.biomedcentral.com/articles/10.1186/s13223-017-0213-x

10 Warning Signs of a Primary Immunodeficiency (PI/CVID)

10 most “common” symptoms that present as symptoms of Primary Immunodeficiency (PI). PIs are complex and manifest differently, severely, and typically with unknown episodes/illnesses that are not as black and white as the warning signs. The warning signs listed are a good starting point for further evaluation.

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The following information displays the 10 most “common” symptoms that present as symptoms of Primary immunodeficiency (PI). Research tends to agree on these broad “symptoms”. PIs are complex and manifest differently, severely, and typically with unknown episodes/illnesses that are not as black and white as the “Warning Signs”. If one has any 2 of the 10 warning signs, follow-up with the specific blood work described below.

10-Warning-Signs—Illustrated–2-

10-Warning-Signs-2014-jfm
Primary-Immunodeficiencies—Know-the-Warning-Signs

Remember when stated, the 10 Warning Signs are not “black and white”? PIs are rare. Research is still in its infancy, and the Immune System is complex. I have witnessed children with debilitating arthritis and joint conditions, “strange” or “unknown” organ illnesses, enlarged spleens, heart and/or severe organ irregularities, and more. A PI is not a one size fits all. Neither are the comorbidities.
Comorbidites are the result (secondary or caused by) a Primary Immune Deficiency.
How can you confirm a PI? A simple blood test! The AAAI recommends, “An accurate diagnosis can be made through screening tests that measure immunoglobulin (IGg) levels or the number of B cells in the blood.”

I recommend saving (paper format) all serum testing, and filing in a safe place. The reason for saving previous serum or blood work, you can document decreases or increases, of the Immunoglobulin (IGg, IGa, IGm)or WBC (check the Albumin, Globulin, and the Ratios of A/G) of serum tests. This is especially true for children, as the immune system is not considered fully developed at younger ages. Which makes diagnosing a PI in young children more of a challenge. Even when children show definitive symptoms early in life. Another reason it’s nearly impossible to find IGg results 10 years later.
A PI is the umbrella diagnosis for all specific rare diseases that fall under the criteria of a PI. The second “umbrella diagnosis” under PI is Common Variable Immune Deficiency (CVID). CVID symptoms vary widely, and is less understood (as most PIs). The CVID diagnosis is confirmed if the IGg levels are significantly decreased in either IGg and IGa, OR IGg and IGm.

Further serum and clinical testing will involve what is called a, “Vaccine Challenge”. If the “Vaccine Challenge” confirms the inability for the person to create “memory” (B) cells to previous vaccinations, the diagnosis may be CVID. There may be other PI deficiencies, or genetic defects interacting, in addition to CVID diagnosis.

The rarity of a specific PI, or CVID, and diagnosing by medical professionals remains a challenge. Many physicians never see patients with CVID, and are unaware of the disease. It’s imperative to seek a Clinical Immunologist that is familiar with CVID or PIs if the IGg results are abnormal. You can request the immunoglobulin blood work at a primary doctor (get a copy!.

Posted below you will find reference points, of testing, to discuss with your primary/preferred physician.

Physician-Algorithm

When to Consider a PI in .pdf format for (Specialists):
Diagnostic-Algorithm-for-Specialty-Care-Physicians

If one is ultimately diagnosed with a PI, A patients decision of specialists, is a personal, private decision. The decisions involve many factors; Knowledge of the specialists, geographic location, experience, insurance, and your personal preferences.
I do NOT recommend sourcing any specialist from any one entity.

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*Disclosure: I am not a medical physician, nor pretend to be one. Consult with a medical physician with any questions, professional knowledge, follow-up and/or advice.

Attributions:
American Academy of Allergy Asthma and Allergy (AAAAI): https://www.aaaai.org/
JMF: http://www.info4pi.org/library/educational-materials/educational-books

***I do NOT endorse, am not employed, and have zero affiliation with the sources of the information presented. The pictorial information are public resources that helps the reader to understand basic warning signs of a PI.